Studies on calcitonin in the carotid body chief cells during development and in SIDS immunohistochemical localization, quantitative analysis and detection of calcitonin mRNA by in situ hybridization.

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Published by National Library of Canada = Bibliothèque nationale du Canada in Ottawa .

Written in English

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SeriesCanadian theses = Thèses canadiennes
The Physical Object
Pagination2 microfiches : negative.
ID Numbers
Open LibraryOL14754403M
ISBN 100315783788

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Calcitonin mRNA was detected in human and monkey carotid bodies by in situ hybridization histochemistry, using a 35S-labeled oligonucleotide probe for human calcitonin. In both human and monkey carotid body, moderate to high hybridization signal for calcitonin mRNA was observed in all cases.

The hybridization signal in the formalin-fixed, paraffin-embedded samples was Cited by: 2. The pathomechanism of sudden infant death syndrome (SIDS) has not been clarified yet. The high rate of early progenitor cells in carotid body has been reported as a pathognomic feature for SIDS. Calcitonin acts to decrease serum calcium concentrations in several ways.

For example, it inhibits the activity of the osteoclasts in bone tissue, thereby preventing the resorption (breakdown) of bone, and inhibits the reabsorption of calcium by the cells of the kidney, resulting in increased calcium excretion in the effects of calcitonin counter the effects of parathyroid hormone.

The carotid body in Sudden Infant Death Syndrome. neurons have high mortality during development, severe neonatal apneas (Hodges et al., ), and. A recent study on the innervation of the human carotid body confirms this heterogeneity and variability (Toorop et al., ), but, in general, corroborates the observations published by Fernando Author: Hiroyuki Ichikawa.

The main structural changes during maturation are listed in Table instance, the total volume of the infant carotid body has been reported to increase from mm 3 at birth to mm 3 at years.

The volume of glomic tissue also increases in the same age range from mm 3 to mm 3 (Dinsdale et al., ).Gradual increments in combined weights and the total and functional. Calcitonin is synthesized by the parafollicular cells (C-cells) of the thyroid gland in mammals 2., 3., 5., 6.

and by the C-cells associated with the ultimobranchial gland in lower vertebrates 7., C-cells are derived from the neural crest and migrate forward to localize in the ultimobranchial body in lower vertebrates and as parafollicular cells in man and related species Initial studies on sheep suggested the parathyroid gland as the source of calcitonin.

Later, the source of this calcium-lowering factor localized to the thyroid gland. During the past three decades, extensive investigations have enhanced our understanding of the structure, biosynthesis, physiology and pharmacology of calcitonin.

In MEA I, adenohypophyseal cells, pancreatic and gut endocrine cells, parathyroid chief cells, and sometimes other APUD cells may be involved (Pearse, ; Bolande, ) and in MEA II, thyroid C cells, suprarenal chromaffin cells, carotid body chief cells, and parathyroid chief cells (Pearse, ; Montgomery and Welbourn, ).

Less. Calcitonin is a unique hormone, because its importance is not well known. While doctors know what it does, they do not understand why we have it, and few symptoms occur if levels are high or low.

The body appears to function normally, even with high or low levels of this thyroid hormone. Calcitonin is a 32 amino acid peptide hormone secreted by parafollicular cells (also known as C cells) of the thyroid gland in humans, and in many other animals in the ultimopharyngeal body.

It acts to reduce blood calcium (Ca 2+), opposing the effects of parathyroid hormone (PTH). Many cells immunoreactive for the S protein, a sustentacular cell marker, appear in the mutant carotid body during fetal development. The Mash1 gene is thus required for the genesis of glomus.

Calcitonin receptor (Calcr) is expressed in adult muscle stem cells (muscle satellite cells [MuSCs]). To elucidate the role of Calcr, we conditionally depleted Calcr from adult MuSCs and found that impaired regeneration after muscle injury correlated with the decreased number of MuSCs in Calcr-conditional knockout (cKO) mice.

The purpose of this study was to establish the presence of mRNA coding for the D2-dopamine receptor (D2-R) in the carotid body and petrosal ganglia in the cat, and compare the levels of expression.

KEY ROLE OF CGRP IN MIGRAINE. Results from several human studies have demonstrated that serum levels of CGRP obtained from the external jugular vein are elevated in patients during migraine (with and without aura) as well as cluster headaches.

8–11 However, in one study, no difference was found between CGRP levels in external jugular or cubital fossa blood during or outside of an attack in.

Cell Reports Article Calcitonin Receptor Signaling Inhibits Muscle Stem Cells from Escaping the Quiescent State and the Niche Masahiko Yamaguchi,1,7 Yoko Watanabe,1,7 Takuji Ohtani,1,7 Akiyoshi Uezumi,2 Norihisa Mikami,1 Miki Nakamura,1 Takahiko Sato,3 Masahito Ikawa,4 Mikio Hoshino,5 Kunihiro Tsuchida,2 Yuko Miyagoe-Suzuki,6 Kazutake Tsujikawa,1 Shin’ichi Takeda,6 Hiroshi.

Calcitonin helps control how the body uses calcium. Calcitonin is a type of tumor marker. Tumor markers are substances made by cancer cells or by normal cells in response to cancer in the body. If too much calcitonin is found in the blood, it may be a sign.

Calcitonin is produced by the parafollicular C cells and represents the classical clinical marker for medullary thyroid carcinoma. Here, the authors describe how measurement of basal and. Intracellular calcium homeostasis is essential for proper cell function.

We investigated the effects of heat shock on the development of and the intracellular Ca 2+ levels in bovine preimplantation embryos in vitro and the effects of calcitonin (CT), a receptor-mediated Ca 2+ regulator, on heat shock-induced events.

Heat shock ( C for 10 h between 20 and 30 h postinsemination) of in vitro. This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors.

The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density.

Calcitonin is a hormone produced by special cells in your thyroid gland called C-cells. The thyroid gland is a small butterfly-shaped gland that lies over and flat against the windpipe in the throat.

Your thyroid gland produces calcitonin and several hormones that help control the rate of metabolism, primarily thyroxine (T4) and. Cross-talk between neurons and ILC2s regulates tissue inflammation. Here, Wallrapp et al.

show that the neuropeptide CGRP negatively regulates ILC2 responses to alarmins and inhibits airway inflammation in vivo. Mice lacking the CGRP receptor have exacerbated responses to alarmins, indicating this is an important pathway that controls type 2 inflammation. Historical perspectives.

In this issue of the JCI, the elegant publication by Hoff and colleagues (), by serendipity or on purpose, falls on the 40th anniversary of the discovery of calcitonin (CT) as a hypocalcemic principle from the parathyroid gland ().The parathyroid origin of calcitonin was revisited shortly thereafter, and a thyroid C cell origin was firmly established (3, 4).

CATN: Calcitonin is a polypeptide hormone secreted by the parafollicular cells (also referred to as calcitonin cells or C cells) of the thyroid gland. The main action of calcitonin is the inhibition of bone resorption by regulating the number and activity of osteoclasts.

Calcitonin is secreted in direct response to serum hypercalcemia and may prevent large oscillations in serum calcium levels. Calcitonin comes from the parafollicular cells, or C cells, of the thyroid gland which is a gland located in the neck that looks like two thumbs hooked together in the shape of a “V”.

The thyroid gland is made up of thousands of follicles, which are small spheres lined with follicular cells. Calcitonin gene-related peptide immunoreactive cells could be identified throughout the period of development studies (20 weeks gestation to 3 months of age), but were present in only limited numbers in less than 50% of individuals (n = 23).

Studies have shown that calcitonin antibody reacts with the human protein calcitonin and labels C-cells in normal thyroid. Calcitonin antibody has been reported to be particularly useful in differentiating medullary carcinoma from papillary and follicular thyroid cancer.

Most medullary carcinomas are positive for calcitonin; conversely, most. CATLN: Calcitonin is a polypeptide hormone secreted by the parafollicular cells (also referred to as calcitonin cells or C-cells) of the thyroid gland.

Malignant tumors arising from thyroid C-cells (medullary thyroid carcinoma: MTC) usually produce elevated levels of calcitonin.

MTC is an uncommon malignant thyroid tumor, comprising less than 5% of all thyroid malignancies. Calcitonin is secreted by thyroidal parafollicular cells of neuroectodermal origin, probably in response to hypercalcemia. The IHC demonstration of calcitonin is important: (1) For identification of early or microscopic medullary thyroid cancer (MTC), (2) To identify an MTC in the absence of amyloid deposits, (3) To distinguish non-typical forms of MTC (e.g., predominantly spindle cell or.

Introduction. Ca 2+ plays a crucial role in processes ranging from the formation and maintenance of the skeleton to the temporal and spatial regulation of neuronal function.

Consequently, the maintenance of extracellular Ca 2+ concentration is of critical importance for many vital functions of the animal body.

1 In the model of Ca 2+ reabsorption in mammalian kidneys, Ca 2+ enters the cell. The malignant transformation of thyroid C cells is associated with an increase in human calcitonin (hCT), which can thus be helpful in the early diagnosis of medullary thyroid carcinoma (MTC).

For this reason, hCT levels should be determined in all patients with nodular goitre. Hashimoto’s thyroiditis, nodular goitre and proton pump inhibitor (PPI) therapy are factors reported to influence.

STUDY. Flashcards. Learn. Write. Spell. Test. PLAY. Match. Gravity. Created by. bsing Terms in this set (5) Where does calcitonin come from. Parafollicular cells of thyroid. What is the chemistry of calcitonin. Polypeptide 32aa.

What is the effects of extracellular calcitonin. Calcitonin-deacreases osteoclastic activity -decreases bone. Start studying calcitonin, ca. Learn vocabulary, terms, and more with flashcards, games, and other study tools. Start studying Calcium: Thyroid calcitonin & PTH (Exam 2).

Learn vocabulary, terms, and more with flashcards, games, and other study tools. The APUD cell family rapidly enlarged to some 40 members, including adrenal medulla and gut chromaffin cells, thyroid C cells, endocrine cells of the anterior pituitary, gut and pancreatic endocrine cells, carotid body chief cells, Merkel cells, melanocytes, endocrine cells of the placenta and thymus and sympathetic ganglia cells.

Cards cover the site of synthesis, primary & secondary functions, means, & control of secretion questions for Calcitonin (TCT). Calcitonin and acute hypercalcemia. Studies during the past 50 years have shown that CT modifies the development of hypercalcemia.

Ina calcium infusion in thyroparathyroidectomized dogs was shown to result in a greater magnitude of hypercalcemia and a longer time to return to baseline values than in normal dogs.

The regulatory role of calcitonin in bone homeostasis is well studied, yet its molecular activity is poorly understood. The authors show that calcitonin regulates bone cells.

43 year old woman with medullary thyroid carcinoma, small cell variant (Acta Cytol ;) 57 year old woman with mixed medullary - papillary carcinoma thyroid (J Lab Physicians ;) Prognostic value of calcitonin immunostaining in medullary carcinoma of the thyroid (J Clin Endocrinol Metab ;) Diagnosis and management of medullary thyroid carcinoma (Diagn.

Start studying PTH & Calcitonin - Chapter Learn vocabulary, terms, and more with flashcards, games, and other study tools. calcitonin [kal″sĭ-to´nin] a polypeptide hormone secreted by the parafollicular or C cells of the thyroid gland; it is involved in plasma calcium homeostasis and acts to decrease the rate of bone resorption.

Preparations of calcitonin are called either calcitonin-human or calcitonin-salmon; the former is a synthetic polypeptide with the same.Alternative names for calcitonin. CT; thyrocalcitonin. What is calcitonin? Calcitonin is a hormone that is produced in humans by the parafollicular cells (commonly known as C-cells) of the thyroid gland.

Calcitonin is involved in helping to regulate levels of calcium and phosphate in the blood, opposing the action of parathyroid means that it acts to reduce calcium levels in the. In the present study, while the effect of CGRP antagonism on the magnitude of the increase in haemoglobin concentration during acute hypoxaemia further supports the involvement of CGRP in the activation of the sympathetic nervous system in fetal sheep, whether the spleen and venous circulations act as important reservoirs of red blood cells.

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